Data for 3-Hydroxypropionic Acid Recovery from Fermentation Broth Through Novel Downstream Processing: Technoeconomic Analysis

Mahata, C., Mishra, S., Singh. V. Jan. 25, 2026. Data from: “3-Hydroxypropionic Acid Recovery from Fermentation Broth Through Novel Downstream Processing: Technoeconomic Analysis.” GitHub.

This study develops and validates a simplified, fully solvent-free downstream processing (DSP) strategy for high-purity recovery of 3-hydroxypropionic acid (3-HP) from real fermentation broth containing 62.3 g/L of 3-HP. Optimized activated carbon treatment achieved 98% color removal, while Amberlite IRA-67 was operated at pH 4.5 and 30 °C to minimize product loss. This is the first integrated demonstration of a fully solvent-free DSP enabling recovery of bio-based 3-HP as both a solid sodium salt and a concentrated aqueous solution, supported by techno-economic analysis. At lab scale, the process achieved 77.3% recovery of sodium 3-HP with 83.2% (w/w) purity and produced a 30% (w/v) aqueous solution. Techno-economic analysis yielded minimum selling prices of $0.551/kg for the solution and $0.892/kg for the salt, both below target thresholds for cost-competitive bio-acrylic acid production. Overall, these results demonstrate an efficient, scalable, and economically viable industrial pathway for 3-HP recovery.

GitHub: SPD files (SuperPro Designer v.12.0), system report

Illinois Data Bank: TEA parameters/summary, broth components, sensitivity analysis parameters