ECNet: Evolutionary Context-Integrated Neural Network

Themes: Conversion

Keywords: Software


Luo, Y. Aug. 30, 2021. “loyunan/ECNet: First release (v0.1).” Zenodo. DOI: 10.5281/zenodo.5294461


An overview of ECNet, an evolutionary context-integrated, deep learning model for protein engineering.

ECNet (evolutionary context-integrated neural network) is a deep learning model that guides protein engineering by predicting protein fitness from the sequence. It integrates local evolutionary context from homologous sequences that explicitly model residue-residue epistasis for the protein of interest with the global evolutionary context that encodes rich semantic and structural features from the enormous protein sequence universe.


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